Skin integrity and its relevance in health and disease

Time: 09:30

Date: 21 Novembre 2018

Theatre: Turquoise 2

21-11-2018 09:30 21-11-2018 Europe/London Skin integrity and its relevance in health and disease

The stratum corneum barrier is a dynamic structure resulting from the processes of cornification and desquamation intimately linked; the control of its formation in response to barrier perturbation is directly relevant to the aetiology of several skin diseases as well to the development of new strategies for skin treatment and barrier fortification.  A defective maturation… Leggi tutto »

Making Cosmetics

The stratum corneum barrier is a dynamic structure resulting from the processes of cornification and desquamation intimately linked; the control of its formation in response to barrier perturbation is directly relevant to the aetiology of several skin diseases as well to the development of new strategies for skin treatment and barrier fortification.  A defective maturation of the cornified envelope may account for impairment of barrier function in some inflammatory skin disorders: immature cornified envelopes are present in psoriasis and atopic dermatitis and are often associated with parakeratosis.

Intercellular lipids play a major role in maintaining and modulating barrier efficiency: the process required for the formation of the structures of the intercellular spaces goes from the synthesis of precursor lipids in keratinocytes, assembly of these lipids into lamellar bodies and exocytosis of the lamellar bodies with processing of these lipids to organize lamellar structures in the intercellular spaces of the stratum corneum. Cholesterol, ceramides, essential and non-essential fatty acids play a key role in the formation of these bilayers. Irritant contact dermatitis and atopic dermatitis can easily generate on a disrupted barrier, due both to enhanced transcutaneous penetration of aggressive chemicals and to xerosis and desquamation as a consequence of increased water loss from skin surface. In this light, irritant contact dermatitis can be seen as a preliminary step towards the development of a permanent sensitisation.

Potentially harmful sensitizers can have easy access to living epidermal structures in irritated skin leading to permanent sensitisation and skin damage. Any therapeutic approach which restores stratum corneum barrier function not only can improve the “cosmetic” appearance of the skin, but can  treat the skin as well, by reducing transcutaneous penetration of sensitizers and chemicals and decrease the release of proinflammatory mediators induced by a disrupted barrier.

Speakers

  • Enzo Berardesca

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